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Dexmedetomidine Attenuates Myocardial Injury Induced by Renal Ischemia/Reperfusion by Inhibiting the HMGB1-TLR4-MyD88-NF-kappa B Signaling Pathway

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. To investigate the effect of dexmedetomidine (DEX) on myocardial injury induced by renal ischemia/reperfusion (I/R) and to explore the role......

Thalidomide Reduces Activation of Murine Pancreatic Stellate Cells by Inhibiting the TGF-beta/Smad Pathway

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. The aim of this study was to investigate the effects and mechanism of thalidomide on pancreatic stellate cell (PSC) activation in mice and ......

Expression of RAB7L1 in Patients with Pituitary Adenomas

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (2)

Pituitary adenomas (PA) are neoplasms that arise predominantly in the adenohypophysis. They are generally divided into three categories depending on t......

Effect of NTSR1 on the Proliferation and Invasion of Gastric Adenocarcinoma Cells, the Underlying Mechanism, and Clinical Role

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (2)

Objective. This work aimed to explore the effect of NTSR1 on oncogenesis and the potential clinical role of gastric adenocarcinoma (GAC). Methods. Imm......

Fractionated Irradiation Enhances Invasion and Migration by Inducing Epithelial-Mesenchymal Transition and Stemness-Like Properties in A549 Cells

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (4)

Objective. Radioresistance-induced locoregional recurrence remains a major cause of low survival rates. However, the mechanism of treatment failure in......

Development of BRAF V600E Mutation in NRAS Q61L Mutated Rectal Cancer

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (2)

BRAF and NRAS are oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. Coexistent mutations of BRAF and NRAS in a single colorectal cancer patie......

Long Non-Coding RNA Small Nucleolar RNA Host Gene 1 Alleviates Sepsis-Associated Myocardial Injury by Modulating the miR-181a-5p/XIAP Axis in vitro

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (2)

Objective. Sepsis is a systemic inflammatory response syndrome that results in severe myocardial injury. This study aimed to explore the role and mech......

PLAC1 Regulates the Occurrence of Fetal Growth Restriction by Inhibiting the Apoptosis of Trophoblast Cells

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (2)

Objective. Fetal growth restriction (FGR) refers to impaired and insufficient intrauterine growth potential caused by a variety of adverse factors and......

Two Novel Mutations (G774A and A1685G) Causing Coagulation Factor XII Deficiency in a Patient with Acute Inferior Myocardial Infarction

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. To identify the gene mutation of the coagulation factor XII (FXII) in a patient with FXII deficiency and acute inferior myocardial infarcti......

N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-alpha Expressions

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (4)

Objective. To compare the efficacy and functional outcomes of dl-3-n-Butylphthalide (NBP) and human urinary kallidinogenase (HUK) on ischemic stroke p......

Diagnostic Values of the Prealbumin-to-Fibrinogen, Albumin-to-Fibrinogen, and Monocyte-to-Lymphocyte Ratios in Gastric Cancer

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. This study aimed to assess the diagnostic value of the prealbumin-to-fibrinogen ratio (PFR), monocyte-to-lymphocyte ratio (MLR), and albumi......

Inhibition of microRNA-130b Alleviated Podocyte Injury Induced by Puromycin Aminonucleoside in vitro

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. To investigate the effect of microRNA-130b (miR-130b) on podocyte injury induced by puromycin aminonucleoside (PAN) and its possible mechan......

Application of Capillary Electrophoresis in Monoclonal Gammopathies and the Cutoff Value of Monoclonal Protein in Differential Diagnosis of Multiple Myeloma and Other Monoclonal Gammopathies

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. Monoclonal protein (MP) exists in various diseases, and capillary electrophoresis (CE) has been widely used to detect MP. However, there is......

A Novel Mutation in the KCNH2 Gene Associated with Long QT Syndrome: A Case Report

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (2)

Objective. Long QT syndrome is a cardiovascular disease with a prolonged QT interval. Case report. We report a 22-year-old woman presenting with frequ......

CircMYLK Promotes Cell Proliferation, Migration, and Invasion in Colorectal Cancer

期刊: ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2021; 51 (3)

Objective. To investigate the role of circular RNA MYLK (circMYLK) in colorectal cancer (CRC). Methods. Patients with CRC were enrolled and cancerous ......

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